Clindamycin has a bacteriostatic effect. It interferes with bacterial
protein synthesis (in a similar way to erythromycin, azithromycin
and chloramphenicol), by binding preferentially to the 50S subunit
of the bacterial ribosome. The structures of the complexes between
several antibiotics (including clindamycin) and a Deinococcus radiodurans
ribosome have been solved by X-ray crystallography by a team from
the Max Planck Working Groups for Structural Molecular Biology,
and published in the journal Nature.
Cleocin is an antibiotic that fights bacteria in the body. Cleocin
is used to treat serious infections caused by bacteria. Cleocin
Cream is used for treating vaginal infections caused by certain
bacteria.Take Cleocin by mouth with or without food. Take Cleocin
with a full glass of water (8 oz/240 mL). Cleocin works best if
it is taken at the same time each day. To clear up your infection
completely, take Cleocin for the full course of treatment. Keep
taking it even if you feel better in a few days.
Although side effects from Cleocin are not common, they can occur.
Tell your doctor if any of these symptoms are severe or do not go
away:
upset stomach
vomiting
gas
diarrhea
Tell your doctor if any these symptoms are severe or do not go away
while using Cleocin vaginally or on your skin:
dry skin
redness or irritation
peeling
oiliness
itching or burning
If you experience the following symptom, or any of those listed
in the IMPORTANT WARNING section, stop taking Cleocin and call your
doctor immediately:
Reproduction studies have been performed in rats and mice using subcutaneous and oral doses of clindamycin ranging from 100 to 600 mg/kg/day and have revealed no evidence of impaired fertility or harm to the fetus due to clindamycin. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.